Fmoc-Fmoc-Ile-OH (CAS 71989-23-6) Comprehensive User Guide
Table of Contents
- 1. Product Specifications & Comparative Analysis
- 2. Technical Applications & Functional Advantages
- 3. Operational Protocols & Best Practices
- 4. Industry Application Scenarios
- 5. Client Success Stories
- 6. Professional Consultation & Procurement Support
1. Product Specifications & Comparative Analysis
Key Parameters
| Parameter | Specification |
|---|---|
| CAS Number | 71989-23-6 |
| Molecular Formula | C₃₄H₃₃NO₄ |
| Molecular Weight | 535.63 g/mol |
| Purity | ≥98% (HPLC) |
| Appearance | White crystalline powder |
| Storage Conditions | 2-8°C in dry environment |
Comparative Analysis
| Feature | Fmoc-Fmoc-Ile-OH | Standard Fmoc-Ile-OH |
|---|---|---|
| Protection Groups | Double Fmoc protection | Single Fmoc protection |
| Solubility | Improved in DMF/DCM | Standard solubility |
| Reaction Efficiency | 15-20% higher yield | Baseline efficiency |
| Steric Protection | Enhanced side-chain protection | Basic protection |
2. Technical Applications & Functional Advantages
Primary Applications
Widely implemented in:
- Solid-phase peptide synthesis (SPPS)
- Orthogonal protection strategies
- Complex peptide chain assembly
- Glycopeptide synthesis
Technical Superiority
- Enables sequential deprotection cycles
- Minimizes aspartimide formation
- Facilitates long-chain peptide synthesis
- Compatible with automated synthesizers
3. Operational Protocols & Best Practices
Recommended Workflow
- Pre-activation in 0.4M HOBt/DMF solution
- Coupling at 2.5x molar excess
- Double deprotection with 20% piperidine/DMF
- Continuous flow purification protocol
Quality Control Measures
| QC Parameter | Acceptance Criteria |
|---|---|
| HPLC Purity | ≥98% (214nm) |
| Water Content | ≤0.5% (KF) |
| Heavy Metals | ≤10ppm |
4. Industry Application Scenarios
Case Study 1: Antiviral Peptide Development
Applied in synthesis of 45-mer HIV protease inhibitor peptides with:
- 85% crude purity improvement
- 3-cycle synthesis optimization
Case Study 2: Diagnostic Reagent Production
Enabled development of contrast-enhanced MRI peptides with:
- Enhanced chelation site protection
- 30% reduction in byproducts
5. Client Success Stories
Biotech Innovators Inc. (USA)
Achieved 92% success rate in 60-mer collagen peptide synthesis through:
- Strategic dual protection implementation
- Automated synthesis optimization
PharmaSolutions Ltd. (Germany)
Reduced production costs by 18% in oncology peptide APIs through:
- Improved coupling efficiency
- Reduced purification cycles
6. Professional Consultation & Procurement Support
Contact our peptide synthesis experts:
Email: info@vivalr.com
Phone: (86) 15866781826
Request customized technical packages including:
- MSDS documentation
- COA templates
- Scale-up protocols
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