Methyl Trifluoroacetate (CAS 431-47-0) Comprehensive Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Industry Uses
- 3. Performance Comparison with Similar Esters
- 4. Operational Guidelines & Safety Protocols
- 5. Real-World Case Studies
- 6. Technical Inquiry & Procurement Support
1. Product Overview & Specifications
| Parameter | Methyl Trifluoroacetate | Methyl Acetate | Methyl Trichloroacetate |
|---|---|---|---|
| CAS Number | 431-47-0 | 79-20-9 | 598-99-2 |
| Molecular Formula | C3H3F3O2 | C3H6O2 | C3H3Cl3O2 |
| Molecular Weight | 142.05 g/mol | 74.08 g/mol | 197.41 g/mol |
| Boiling Point | 40-42°C | 57°C | 152°C |
| Flash Point | -4°C | -10°C | 72°C |
| Density | 1.273 g/cm³ | 0.932 g/cm³ | 1.492 g/cm³ |
2. Key Applications & Industry Uses
2.1 Pharmaceutical Intermediate
Widely used in synthesizing fluorinated drug molecules due to its superior leaving group properties in nucleophilic substitution reactions.
2.2 Agrochemical Production
Essential for creating fluorinated pesticides with enhanced environmental stability and bioactivity.
2.3 Specialty Chemical Synthesis
Serves as trifluoromethylating agent in advanced material production including liquid crystals and OLED materials.
3. Performance Comparison with Similar Esters
| Feature | Methyl Trifluoroacetate | Ethyl Trifluoroacetate |
|---|---|---|
| Reaction Rate | Faster acyl transfer | Slower kinetics |
| Byproduct Formation | Lower (stable CF3 group) | Higher |
| Solvent Compatibility | Wider polarity range | Limited to polar aprotic |
4. Operational Guidelines & Safety Protocols
4.1 Storage Requirements
Store in sealed containers under inert gas (N2/Ar) at 2-8°C with humidity below 40% RH.
4.2 Handling Precautions
Use chemical-resistant PPE including fluoropolymer gloves and full-face respirators with A1B1E1K1 filters.
5. Real-World Case Studies
5.1 Pharma Intermediate Production (Client: EuroFarma Ltd.)
Challenge: Required high-purity trifluoromethylated intermediates for antiviral drug development
Solution: Implemented methyl trifluoroacetate in continuous flow reactors
Result: 92% yield improvement vs batch processing
5.2 Electronic Materials Synthesis (Client: NanoFlux Technologies)
Challenge: Needed low-boiling fluorinating agent for vacuum deposition processes
Solution: Adopted methyl trifluoroacetate as precursor
Result: Reduced process temperature by 35°C with 99.7% purity
6. Technical Inquiry & Procurement Support
For technical specifications sheets or bulk pricing:
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• COA (Certificate of Analysis)
• MSDS (Material Safety Data Sheet)
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