Bestatin Hydrochloride (CAS 65391-42-6): Comprehensive Product Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Bestatin Hydrochloride | Competitor A | Competitor B |
|---|---|---|---|
| CAS Number | 65391-42-6 | Not Disclosed | Purity ≤95% |
| Molecular Formula | C16H25ClN2O4 | N/A | N/A |
| Purity (HPLC) | ≥98% | ≥97% | ≥95% |
| Solubility | Water (25 mg/mL), DMSO, methanol | Limited data | Partial solubility |
| Storage | -20°C, desiccated | Ambient | 4°C |
2. Key Applications & Mechanism of Action
Primary Functions:
- Potent inhibitor of CD13/Aminopeptidase N (IC50: 60 nM) and leukotriene A4 hydrolase
- Enhances all-trans retinoic acid (ATRA)-induced differentiation in APL NB4 cells
- Suppresses p38 MAPK phosphorylation in cancer research models
- Reduces VEGF/HIF-1α expression in diabetic retinopathy studies
Research Areas:
- Oncology: Tumor microenvironment modulation
- Immunology: Antigen presentation enhancement
- Metabolic Disorders: Diabetic complication management
3. Research Case Studies
Case 1: Leukemia Differentiation (2024)
Protocol: 600 μM treatment in ATRA-sensitive NB4 cells
Result: 72% increase in differentiation markers vs control (p<0.01)
Case 2: Diabetic Retinopathy Model
Dosage: 20 μM intravitreal injection
Outcome: 54% reduction in VEGF expression (qPCR analysis)
4. Customer Success Stories
Shanghai Institute of Materia Medica
Application: High-throughput screening of leukemia therapeutics
Outcome: Achieved 89% target inhibition rate in 72hr assays
Zhejiang University Medical Center
Application: Diabetic complication pathways analysis
Result: Published in Cell Metabolism (IF: 31.4), 2023
5. Technical Support & Inquiries
For bulk orders (>100g) or customized formulations:
Email: info@vivalr.com
Tel: (86) 15866781826
MSDS and COA available upon request. GMP-grade batches produced quarterly.
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