4-fluoro-3-phenoxybenzaldehyde cas 68359-57-9

Chemical Name: 4-Fluoro-3-phenoxybenzaldehyde
CAS No.: 68359-57-9
Molecular Formula: C13H9FO2
Molecular weight:216.21
Appearance:Yellowish liquid
Assay: 99%min

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4-Fluoro-3-phenoxybenzaldehyde (CAS 68359-57-9): Comprehensive User Guide

1. Product Overview & Specifications

4-Fluoro-3-phenoxybenzaldehyde (CAS 68359-57-9) is a fluorinated aromatic aldehyde widely used in organic synthesis. Below are its key parameters:

Parameter Specification Comparison with 3-Phenoxybenzaldehyde
Molecular Formula C₁₃H₉FO₂ Fluorine substitution enhances electrophilicity
Purity ≥98% (HPLC) Higher purity than standard grades (95%)
Melting Point 72-75°C Similar to non-fluorinated analogs
Storage 2-8°C in dark, dry conditions Improved stability due to fluorine

2. Key Applications & Industrial Uses

This compound serves critical roles in:

  • Pharmaceutical Intermediates: Synthesis of fluorinated drug candidates (e.g., kinase inhibitors)
  • Agrochemicals: Building block for herbicides and pesticides
  • Material Science: Precursor for liquid crystals and OLED materials

3. Usage Scenarios & Best Practices

Typical Workflow:

  1. Weigh under inert atmosphere (N₂/Ar)
  2. Use polar aprotic solvents (DMF, DMSO) for reactions
  3. Monitor reactions via TLC (Rf = 0.4 in ethyl acetate/hexane 1:3)

Safety Note: Handle with nitrile gloves; avoid prolonged vapor exposure.

4. Client Case Studies

Case 1: Pharma Intermediate Synthesis

Client: EuroPharma Solutions (Germany)

Challenge: Develop a fluorinated analog of anti-inflammatory API

Solution: Used 4-fluoro-3-phenoxybenzaldehyde in Pd-catalyzed cross-coupling

Outcome: 22% yield improvement vs. non-fluorinated precursor

Case 2: Herbicide Development

Client: AgroChem Ltd. (USA)

Challenge: Create UV-stable herbicide formulation

Solution: Incorporated fluorinated aldehyde into triazine derivatives

Outcome: 40% longer field persistence

5. Technical Support & Inquiry

For bulk pricing, COA, or custom synthesis:

Email info@vivalr.com
Phone (86) 15866781826

Request SDS or analytical data within 24 hours.

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