Pyridin-2-ol Comprehensive User Guide

Table of Contents

1. Product Specifications & Comparative Analysis

Parameter Pyridin-2-ol Pyridine 2-Hydroxypyridine
CAS Number 142-08-5 110-86-1 16867-03-1
Molecular Formula C5H5NO C5H5N C5H5NO
Boiling Point 280-282°C 115°C 275°C
Pharmaceutical Applications API Intermediate Solvent Limited

2. Industrial Applications

2.1 Pharmaceutical Manufacturing

Key intermediate in synthesizing antiviral agents and kinase inhibitors. Compatible with Buchwald-Hartwig amination for drug discovery.

2.2 Agrochemical Formulations

Essential component in neonicotinoid insecticides (e.g., Imidacloprid derivatives) with enhanced bioactivity against resistant pests.

3. Operational Guidelines

3.1 Safety Protocols

  • GHS Classification: H315-H319-H335 (Skin/Eye irritant, Respiratory sensitizer)
  • PPE Requirements: Nitrile gloves, vapor respirators, chemical goggles

3.2 Storage Conditions

  • Temperature: 2-8°C under inert atmosphere
  • Shelf Life: 24 months in original sealed packaging

4. Application Case Studies

4.1 Pharma Client: Vertex Therapeutics

Application: Synthesis of JAK2 inhibitors for myeloproliferative disorders
Result: 92% yield improvement vs traditional intermediates
Feedback: “Superior regioselectivity in cross-coupling reactions”

4.2 Agrochemical Client: Syngenta AG

Application: Development of 3rd-gen insect growth regulators
Result: 40% cost reduction in production scale-up
Feedback: “Excellent stability under field conditions”

5. Contact for Technical Consultation

Request custom synthesis specifications or bulk pricing:

Technical Support Features:

  • Batch-specific COA documentation
  • Regulatory compliance consulting (REACH, FDA DMF)
  • Customized packaging solutions
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