Parameter | Pyridin-2-ol | Pyridine | 2-Hydroxypyridine |
---|---|---|---|
CAS Number | 142-08-5 | 110-86-1 | 16867-03-1 |
Molecular Formula | C5H5NO | C5H5N | C5H5NO |
Boiling Point | 280-282°C | 115°C | 275°C |
Pharmaceutical Applications | API Intermediate | Solvent | Limited |
Key intermediate in synthesizing antiviral agents and kinase inhibitors. Compatible with Buchwald-Hartwig amination for drug discovery.
Essential component in neonicotinoid insecticides (e.g., Imidacloprid derivatives) with enhanced bioactivity against resistant pests.
Application: Synthesis of JAK2 inhibitors for myeloproliferative disorders
Result: 92% yield improvement vs traditional intermediates
Feedback: "Superior regioselectivity in cross-coupling reactions"
Application: Development of 3rd-gen insect growth regulators
Result: 40% cost reduction in production scale-up
Feedback: "Excellent stability under field conditions"
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