Table of Contents
- 1. Product Overview and Specifications
- 2. Detailed Applications
- 3. Usage Guidelines
- 4. Industry Case Studies
- 5. Client Implementation Examples
- 6. Contact for Technical Consultation
1. Product Overview and Specifications
| Parameter | n-Dodecyl-beta-D-maltoside (DDM) | Comparable Detergents |
|---|---|---|
| CAS Number | 69227-93-6 | Triton X-100: 9002-93-1 OGP: 29529-66-4 |
| Molecular Formula | C24H46O11 | Triton X-100: C14H22O(C2H4O)n |
| Critical Micelle Concentration (CMC) | 0.16 mM | Triton X-100: 0.24 mM OGP: 6-8 mM |
| Protein Compatibility | High (Maintains >90% activity) | Triton X-100: Moderate (60-75% activity) |
2. Detailed Applications
Membrane Protein Research: Optimal for solubilizing integral membrane proteins while preserving structural integrity.
Structural Biology: Preferred detergent in X-ray crystallography (≤0.03% concentration) and Cryo-EM studies.
Diagnostic Kits: Used in ELISA buffers at 0.05-0.1% concentrations for antigen preservation.
3. Usage Guidelines
Recommended Protocols:
| Application | Concentration | Temperature Range |
|---|---|---|
| Membrane Protein Extraction | 1-2% (w/v) | 4-25°C |
| Chromatography Buffer | 0.05-0.1% | 4-37°C |
4. Industry Case Studies
GPCR Structural Analysis: Enabled crystallization of β2-adrenergic receptor at 2.4Å resolution when used with 0.02% DDM/LCP matrix.
Vaccine Development: Critical component in RSV fusion protein stabilization during Phase III trials.
5. Client Implementation Examples
Case 1: ABC Biotech (2023)
Challenge: Solubilize ABC transporter proteins without aggregation
Solution: 1.5% DDM in 20mM HEPES + 150mM NaCl
Result: 92% monomeric recovery rate
Case 2: XYZ Pharma (2022)
Application: Viral envelope protein isolation
Protocol: 0.8% DDM with 0.2% CHS additive
Outcome: 15% increased antigen yield vs. digitonin
6. Contact for Technical Consultation
For formulation optimization or bulk quotations:
Email: info@vivalr.com
Tel: (86) 15866781826
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