6-(Trifluoromethyl)nicotinic acid

Table of Contents

• Product Overview
• Specifications & Comparative Analysis
• Applications of 6-(Trifluoromethyl)nicotinic Acid
• Step-by-Step Usage Guide
• Industry Case Studies
• Request a Quote/Sample

1. Product Overview

6-(Trifluoromethyl)nicotinic acid (CAS 158063-66-2) is a fluorinated derivative of nicotinic acid widely used in pharmaceuticals, agrochemicals, and material science. Key attributes include:

2. Specifications & Comparative Analysis

3. Key Applications

Pharmaceutical Intermediates

Used in synthesis of kinase inhibitors and anti-inflammatory agents, particularly in:

• JAK/STAT signaling pathway modulators
• EGFR tyrosine kinase inhibitors

Agrochemical Development

Critical component in next-generation herbicides and fungicides with enhanced environmental stability.

Material Science

Building block for liquid crystal materials and organic semiconductors in OLED displays.

4. Usage Guidelines

Storage Recommendations

• Store at 2-8°C in original packaging
• Protect from moisture (keep desiccant in container)

Synthetic Protocol Example

1. Charge 1.0g 6-(Trifluoromethyl)nicotinic acid in anhydrous DMF (10mL)
2. Add 1.2eq EDCI and 0.2eq DMAP at 0°C
3. Stir for 24hr at room temperature under N₂
4. Monitor reaction by TLC (EtOAc/hexane 1:1)

5. Industry Case Studies

Case 1: Anticancer Drug Development

Client: Top 10 Global Pharma Company
Application: Synthesis of PARP-7 inhibitor candidate
Results: Achieved 92% yield in key coupling step with 99.8% enantiomeric excess

Case 2: Herbicide Formulation

Client: European Agrochemical Manufacturer
Application: Development of rainfast herbicide
Results: 40% improvement in field persistence vs previous formulation

6. Request Product Information

Custom synthesis available from gram to kilogram scale. Contact our technical team:

• Email: info@vivalr.com
• Phone: (86) 15866781826

Request MSDS, COA, or custom synthesis quotes within 24hrs.