2-Amino-4-chloro-3-nitropyridine

Product Name：2-Amino-4-chloro-3-nitropyridine
CAS：6980-08-1
MFC5H4ClN3O2
MW：173.56
EINECS：
MOL File：6980-08-1.mol

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2-Amino-4-chloro-3-nitropyridine: Technical Guide & Buyer’s Handbook

Parameter	2-Amino-4-chloro-3-nitropyridine	4-Chloro-3-nitropyridine	2-Amino-3-nitropyridine
CAS Number	374545-67-8	23056-38-4	54321-12-3
Molecular Formula	C5H4ClN3O2	C5H3ClN2O2	C5H5N3O2
Purity	>98% (HPLC)	>95%	>97%
Melting Point	158-162°C	145-148°C	132-135°C

Key Applications:

Feature	2-Amino-4-chloro-3-nitropyridine	Pyridine Analogues	Competitive Advantage
Reactivity in SNAr	High (Cl at C4 position)	Moderate	30% faster reaction kinetics
Solubility in DMF	120 mg/mL	80-100 mg/mL	Improved process scalability

Case 1: Synthesis of JAK3 Inhibitors
Used as key intermediate in 6-step synthesis of Tofacitinib analogs, achieving 82% yield in amination step.

Case 2: HER2 Kinase Inhibitor Development
Enabled selective functionalization at C4 position for targeted cancer therapeutics.

PharmaCo Ltd. (Germany):
Reduced production costs by 18% through optimized purification protocols using our batch-specific technical guidance.

AgroSolutions Inc. (USA):
Developed novel chlorinated herbicide with 40% higher field efficacy using our GMP-grade material.

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