2-Bromo-3-hydroxypyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
2-Bromo-3-hydroxypyridine (CAS 13466-43-8) is a halogenated pyridine derivative widely used as a key intermediate in pharmaceutical synthesis and organic chemistry. Below are its technical specifications:
| Parameter | Specification | Comparison: 2-Chloro-3-hydroxypyridine | Comparison: 3-Hydroxypyridine |
|---|---|---|---|
| CAS Number | 13466-43-8 | NA | NA |
| Molecular Formula | C5H4BrNO | C5H4ClNO | C5H5NO |
| Purity | ≥98% (HPLC) | ≥97% | ≥99% |
| Melting Point | 145-148°C | 138-141°C | 130-133°C |
| Key Advantage | Superior reactivity in cross-coupling reactions | Lower cost | No halogen substitution |
2. Applications of 2-Bromo-3-hydroxypyridine
This compound serves critical roles in:
- Pharmaceutical Intermediates: Synthesis of kinase inhibitors and antiviral agents.
- Organic Synthesis: Suzuki-Miyaura cross-coupling reactions.
- Agrochemicals: Building block for herbicides.
- Material Science: Ligand in catalytic systems.
3. Usage Scenarios & Case Studies
Scenario 1: Suzuki Coupling in API Synthesis
Used as a coupling partner with boronic acids to create biphenyl structures in drug candidates.
Scenario 2: Anticancer Drug Development
Integrated into PARP inhibitor molecules through nucleophilic aromatic substitution.
4. Client Success Stories
Case Study 1: Top 10 Pharma Company (USA)
Challenge: Required high-purity brominated pyridine for a Phase III oncology drug.
Solution: Supplied 50kg batches at 99.2% purity under cGMP conditions.
Outcome: Accelerated FDA submission timeline by 18%.
Case Study 2: European Agrochemical Leader
Challenge: Needed cost-effective halogenated intermediates for novel fungicides.
Solution: Custom synthesis with 98.5% purity at 30% lower cost than market alternatives.
Outcome: Enabled commercial launch within 14 months.
5. Contact for Technical Support
Request a quote or technical dossier:
| info@vivalr.com | |
| Phone | (86) 15866781826 |
| Key Advantages |
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