5-Chloropyridine-2-carboxylic acid

Product Name:5-Chloropyridine-2-carboxylic acid
CAS:86873-60-1
MFC6H4ClNO2
MW:157.55
EINECS:217-339-7
MOL File:86873-60-1.mol

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5-Chloropyridine-2-carboxylic Acid: Technical Guide & Applications

1. Key Specifications & Comparative Analysis

Parameter 5-Chloropyridine-2-carboxylic Acid Analogous Compounds
CAS Number 86873-60-1 38275-61-5 (Pyrimidine variant)
Molecular Formula C6H4ClNO2 C5H3ClN2O2
Molecular Weight 157.55 g/mol 158.55 g/mol
Structural Features Chlorinated pyridine core with carboxylic acid group Pyrimidine-based derivative

2. Functional Applications

This heterocyclic compound serves as:

  • Critical intermediate in antihyperglycemic drug synthesis (e.g., Lazabemide hydrochloride)
  • Building block for organocatalysts
  • Precursor for agrochemical active ingredients
  • Coordination ligand in metal-organic frameworks

3. Synthesis Pathways

Primary Production Methods:

  1. From 2-Bromo-5-chloropyridine:

    Reaction with methanol achieves 91% yield of methyl ester derivative
  2. Via Pyridinecarboxyl Chloride:

    Esterification using 5-chloro-2-pyridinecarbonyl chloride

4. Industrial Use Cases

Pharmaceutical Manufacturing

Used in multi-step synthesis of:

  • Lazabemide HCl (Parkinson’s therapeutic)
  • Antidepressant API intermediates

Agrochemical Development

Key component in:

  • Herbicide formulations
  • Fungicide precursors

5. Client Success Stories

Case Study 1: European Pharma Developer

Challenge: Required 98% purity API intermediate under GMP guidelines
Solution: Custom synthesis with chromatography purification
Outcome: 25kg batch delivered with 99.2% HPLC purity

Case Study 2: US Research Institute

Challenge: Needed deuterated analog for metabolic studies
Solution: Isotope labeling service with 13C markers
Outcome: Successful tracer synthesis in 8-week timeline

Technical Consultation & Ordering

Email: info@vivalr.com
Tel: (86) 15866781826

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