5-Chloropyridine-2-carboxylic Acid: Technical Guide & Applications
Table of Contents
1. Key Specifications & Comparative Analysis
| Parameter | 5-Chloropyridine-2-carboxylic Acid | Analogous Compounds |
|---|---|---|
| CAS Number | 86873-60-1 | 38275-61-5 (Pyrimidine variant) |
| Molecular Formula | C6H4ClNO2 | C5H3ClN2O2 |
| Molecular Weight | 157.55 g/mol | 158.55 g/mol |
| Structural Features | Chlorinated pyridine core with carboxylic acid group | Pyrimidine-based derivative |
2. Functional Applications
This heterocyclic compound serves as:
- Critical intermediate in antihyperglycemic drug synthesis (e.g., Lazabemide hydrochloride)
- Building block for organocatalysts
- Precursor for agrochemical active ingredients
- Coordination ligand in metal-organic frameworks
3. Synthesis Pathways
Primary Production Methods:
- From 2-Bromo-5-chloropyridine:
Reaction with methanol achieves 91% yield of methyl ester derivative - Via Pyridinecarboxyl Chloride:
Esterification using 5-chloro-2-pyridinecarbonyl chloride
4. Industrial Use Cases
Pharmaceutical Manufacturing
Used in multi-step synthesis of:
- Lazabemide HCl (Parkinson’s therapeutic)
- Antidepressant API intermediates
Agrochemical Development
Key component in:
- Herbicide formulations
- Fungicide precursors
5. Client Success Stories
Case Study 1: European Pharma Developer
Challenge: Required 98% purity API intermediate under GMP guidelines
Solution: Custom synthesis with chromatography purification
Outcome: 25kg batch delivered with 99.2% HPLC purity
Case Study 2: US Research Institute
Challenge: Needed deuterated analog for metabolic studies
Solution: Isotope labeling service with 13C markers
Outcome: Successful tracer synthesis in 8-week timeline
Technical Consultation & Ordering
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Tel: (86) 15866781826


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