5-BROMO-2-CHLORO-4-PICOLINE

1. Product Overview & Specifications

5-Bromo-2-chloro-4-picoline (CAS: 778611-64-6) is a halogenated pyridine derivative with the molecular formula C₆H₅BrClN and a molecular weight of 206.47 g/mol. It is also known as 2-chloro-4-methyl-5-bromopyridine or 5-bromo-2-chloro-4-methylpyridine. This compound is widely utilized as a versatile intermediate in pharmaceutical and agrochemical synthesis.

Specification Comparison

2. Key Applications

• Pharmaceutical Intermediate: Used in synthesizing active pharmaceutical ingredients (APIs) for antiviral and anticancer therapies.
• Agrochemicals: Key building block for herbicides and fungicides due to its halogenated pyridine backbone.
• Material Science: Facilitates the production of specialty polymers and liquid crystals.
• Research & Development: Serves as a precursor for novel heterocyclic compounds in organic chemistry.

3. Usage Guidelines

Handling Precautions

• Use personal protective equipment (PPE) including gloves, goggles, and lab coats.
• Avoid inhalation or direct contact with skin/eyes.
• Store in tightly sealed containers under nitrogen or argon to prevent degradation.

Synthetic Protocols

Typical synthesis involves halogenation of 4-methylpyridine derivatives. A common route includes:

1. Bromination of 2-chloro-4-picoline using N-bromosuccinimide (NBS) under controlled conditions.
2. Purification via column chromatography or recrystallization.

4. Industry Case Studies

Case 1: Pharmaceutical Manufacturer (Shanghai)

A leading API producer integrated 5-bromo-2-chloro-4-picoline into their synthesis of a tyrosine kinase inhibitor, achieving a 22% yield improvement compared to traditional intermediates.

Case 2: Agrochemical Innovator (Germany)

Used this compound to develop a next-generation fungicide with enhanced bioavailability, reducing application frequency by 40% in field trials.

Case 3: Research Institute (USA)

Leveraged the compound’s reactivity to create a novel class of fluorescent probes for cellular imaging, published in ACS Chemical Biology (2023).

5. Contact for Inquiries

For technical specifications, bulk pricing, or collaboration opportunities: