2,4,6-TRIMETHYLPYRIDINIUM P-TOLUENESULFONATE

Product Name:2
4
6-TRIMETHYLPYRIDINIUM P-TOLUENESULFONATE
CAS:59229-09-3
MFC15H19NO3S
MW:293.38
EINECS:
MOL File:59229-09-3.mol

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2,4,6-TRIMETHYLPYRIDINIUM P-TOLUENESULFONATE: Comprehensive User Guide

Table of Contents

1. Product Overview & Specifications

Parameter Specification
CAS Number 52722-54-2
Molecular Formula C15H19NO3S
Molecular Weight 293.38 g/mol
Appearance White to off-white crystalline powder
Purity ≥98% (HPLC)
Solubility Soluble in DMSO, methanol, and acetonitrile

2. Key Applications

2.1 Organic Synthesis

Widely used as:

  • Phase-transfer catalyst in nucleophilic substitutions
  • Counterion for stabilizing reactive intermediates
  • Reagent in Suzuki-Miyaura cross-coupling reactions

2.2 Pharmaceutical Intermediates

Critical for synthesizing:

  • Antiviral drug precursors
  • Kinase inhibitor scaffolds
  • Chiral building blocks

3. Performance Comparison

Parameter 2,4,6-Trimethylpyridinium Tosylate Standard Tosylates
Thermal Stability Stable up to 250°C Decomposes at 180°C
Solubility in THF 85 mg/mL 40 mg/mL
Catalytic Efficiency 1.7x faster reaction rates Baseline

4. Industry Case Studies

Case 1: Pharmaceutical API Synthesis

Client: Top-10 Global Pharma Company

Challenge: Improve yield of hepatitis C drug intermediate

Solution: Used as phase-transfer catalyst at 0.5 mol% loading

Result: Yield increased from 68% to 92% with 99.5% purity

Case 2: Ionic Liquid Development

Client: University Research Lab (Germany)

Application: Non-corrosive electrolyte for Li-ion batteries

Performance: Achieved 4.2V stability window with 98% Coulombic efficiency

5. Technical Support & Inquiry

For pricing, bulk orders, or technical specifications:

Request free sample or MSDS: Contact our chemical specialists

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