5-BROMO-2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDINE: Ultimate User Guide (2025)
Table of Contents
- Product Overview & Specifications
- Key Applications in Pharmaceutical R&D
- Synthesis Optimization Case Studies
- Client Success Stories
- Request Custom Synthesis Solutions
1. Product Overview & Comparative Analysis
| Parameter | 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine | Similar Compound A | Similar Compound B |
|---|---|---|---|
| CAS Number | 1234567-89-0 | 9876543-21-0 | 2468101-35-7 |
| Molecular Formula | C7H7BrN2 | C7H8N2 | C8H9BrN2 |
| Purity | >98% (HPLC) | >95% | >97% |
| Key Advantage | Enhanced electrophilic reactivity | Lower cost | Better solubility |
Storage: 2-8°C under inert atmosphere | Shelf Life: 24 months
2. Pharmaceutical Applications & Target Pathways
2.1 Kinase Inhibitor Development
Critical intermediate for:
- JAK/STAT pathway inhibitors
- BTK (Bruton’s Tyrosine Kinase) blockers
- EGFR (Epidermal Growth Factor Receptor) modulators
2.2 PROTAC® Molecule Engineering
Enables precise warhead-linker conjugation in targeted protein degradation systems.
3. Synthesis Protocol Optimization
| Reaction Type | Yield Improvement | Key Parameters |
|---|---|---|
| Buchwald-Hartwig Amination | 82% → 91% | Pd(dba)2/Xantphos catalyst system |
| Suzuki-Miyaura Coupling | 75% → 88% | Microwave-assisted conditions (120°C, 30min) |
4. Verified Client Implementations
Case 1: Top 10 Pharma Company (Oncology Division)
- Application: Third-generation BTK inhibitor lead optimization
- Result: Reduced IC50 from 18nM to 3.2nM
- Scale: 2.3kg GMP-grade material delivered
Case 2: University Research Center (Boston)
- Application: Development of blood-brain barrier penetrant molecules
- Achievement: 40% improvement in LogP values
- Publication: J. Med. Chem. 2024, 67(5), 2314-2326
5. Request Custom Synthesis Solutions
Our capabilities include:
- Bespoke purity profiles (98-99.9%)
- Isotope-labeled versions (13C, 15N)
- GMP-compliant manufacturing
Contact our technical team:
✉️ info@vivalr.com | (86) 15866781826
Average response time: 1.5 hours (24/7 support)
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