3,4-Dihydro-2H-pyran

Table of Contents

• 1. Product Overview
• 2. Key Applications
• 3. Case Studies
• 4. Usage Guidelines
• 5. Client Examples
• 6. Request a Quote

1. Product Overview

Basic Properties of 3,4-Dihydro-2H-pyran

Comparative Analysis

2. Key Applications

Organic Synthesis

Widely used as a protecting group for alcohols and amines due to its stability under acidic conditions. Enables selective reactions in multi-step syntheses.

Pharmaceutical Intermediates

Critical in producing antiviral agents, anticancer drugs (e.g., Tamiflu derivatives), and anti-inflammatory compounds. Its ring-opening reactions facilitate chiral center formation.

Polymer Chemistry

Serves as a monomer for specialty polymers with tunable thermal stability and solubility. Used in coatings, adhesives, and drug delivery systems.

3. Case Studies

Case 1: Anticancer Drug Synthesis

Challenge: Selective protection of a tertiary alcohol in a kinase inhibitor precursor.
Solution: 3,4-Dihydro-2H-pyran introduced under mild acidic conditions (PPTS, CH₂Cl₂, 25°C).
Outcome: 92% yield with no epimerization; later deprotected using Amberlyst-15 in methanol.

Case 2: Polymer Crosslinking Agent

Challenge: Develop a UV-stable epoxy resin for outdoor coatings.
Solution: Incorporated 8 wt% 3,4-Dihydro-2H-pyran-derived monomer during polymerization.
Outcome: 40% improvement in weathering resistance vs. traditional THF-based systems.

4. Usage Guidelines

Safety Protocols

• Use in well-ventilated areas; flash point: 1°C (closed cup)
• Incompatible with strong oxidizers – store separately

Storage Recommendations

• Store under nitrogen at 2-8°C in amber glass bottles
• Shelf life: 24 months when unopened

5. Client Examples

PharmaCorp Ltd. (Germany)

Application: Key intermediate in protease inhibitor production
Volume: 300 kg/month
Feedback: “Consistent ≥99.5% purity reduced purification costs by 18%.”

Advanced Polymers Inc. (USA)

Application: Cyclic ether monomer for aerospace adhesives
Volume: 1.2 tonnes/quarter
Result: Achieved Tg of 165°C vs. 140°C with competing monomers.

6. Request a Quote

Contact our technical sales team for pricing, SDS, and custom synthesis options:

• Email: info@vivalr.com
• Phone: (86) 15866781826

Why choose us?
– ISO 9001-certified production
– Batch-to-batch consistency guaranteed
– Global shipping via DHL/FedEx