4-Cyano-7-Azaindole: Comprehensive User Guide for Pharmaceutical and Research Applications

1. Product Overview & Specifications

4-Cyano-7-Azaindole (CAS: Pending verification) is a heterocyclic compound with the molecular formula C8H5N3, featuring a cyano group at the 4-position of the azaindole scaffold. This structural configuration enables unique electronic properties for pharmaceutical intermediates and organic synthesis.

Comparative Analysis of Azaindole Derivatives
Parameter 4-Cyano-7-Azaindole 4-Chloro-6-Cyano-7-Azaindole 4-Methoxy-7-Azaindole
Molecular Weight 143.14 g/mol 177.59 g/mol 148.17 g/mol
CAS Number Under validation 935466-70-9 122379-63-9
Key Functional Group Cyano Chloro + Cyano Methoxy

*Specifications subject to batch-specific analysis. Contact technical support for certified COA.

2. Key Applications

2.1 Pharmaceutical Intermediates

Widely employed in kinase inhibitor development due to its ability to modulate enzyme binding affinity through π-π stacking interactions.

2.2 Material Science

Used in organic semiconductor research for electron-deficient building blocks in OLED architectures.

2.3 Agrochemical Development

Serves as a precursor for novel pesticides targeting insect GABA receptors.

3. Usage Scenarios

3.1 Medicinal Chemistry Protocol

Typical Suzuki coupling reaction conditions:

  • Catalyst: Pd(PPh3)4 (5 mol%)
  • Solvent: DME/H2O (3:1)
  • Temperature: 90°C under N2
  • Yield: 68-72% (HPLC purity >95%)

3.2 Handling Recommendations

  • Storage: -20°C under argon
  • Shelf Life: 24 months when unopened
  • Safety: Use NIOSH-approved respirator when handling powder

4. Customer Case Studies

4.1 Shanghai Yuanye Bio-Technology

Application: Synthesized BTK inhibitors for autoimmune disease research
Result: Achieved IC50 = 12 nM in cellular assays
Scale: 50g pilot batch production

4.2 Wuhan Ruhening Biotech

Application: Developed fluorescent probes for protein kinase detection
Result: λem = 498 nm with quantum yield Φ = 0.42
Scale: 10kg commercial production

5. Technical Inquiry

For bulk pricing, custom synthesis, or analytical data:
info@vivalr.com
(86) 15866781826

Request current lead times:
GMP-grade batches typically ship within 4-6 weeks

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