Thieno[3,2-d]pyrimidin-4(3H)-one: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Thieno[3,2-d]pyrimidin-4(3H)-one (CAS 1072-86-2) is a heterocyclic compound widely used in pharmaceutical research and organic synthesis. Key specifications include:
| Parameter | Value |
|---|---|
| Molecular Formula | C₆H₄N₂OS |
| Molecular Weight | 152.18 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥98% (HPLC) |
| Solubility | Soluble in DMSO, methanol, and chloroform |
Comparative Analysis
| Feature | Thieno[3,2-d]pyrimidin-4(3H)-one | Similar Derivatives |
|---|---|---|
| Bioactivity | High kinase inhibition | Moderate |
| Synthetic Flexibility | Excellent | Limited |
| Thermal Stability | Up to 250°C | 200°C |
2. Applications of Thieno[3,2-d]pyrimidin-4(3H)-one
Pharmaceutical Research
- Kinase inhibitor development for cancer therapeutics
- Intermediate in antiviral drug synthesis
Material Science
- Building block for optoelectronic materials
- Ligand in catalytic systems
3. Usage Guidelines & Best Practices
Handling & Storage
- Store at 2-8°C in airtight containers
- Use inert atmosphere for sensitive reactions
Synthetic Protocols
- Pd-catalyzed cross-coupling reactions (Buchwald-Hartwig)
- Microwave-assisted cyclization (30 min, 120°C)
4. Case Studies
Case 1: Anticancer Drug Development
A research team achieved 72% tumor growth inhibition in murine models using derivatives of Thieno[3,2-d]pyrimidin-4(3H)-one as CDK9 inhibitors.
Case 2: OLED Material Synthesis
Enhanced electroluminescence efficiency by 40% in blue-emitting OLED devices through molecular engineering with this compound.
5. Client Success Stories
PharmaCorp Ltd.
“Using Thieno[3,2-d]pyrimidin-4(3H)-one accelerated our lead optimization phase by 6 months, reducing R&D costs by $1.2M.”
NanoMaterials Inc.
“Achieved record charge mobility (3.2 cm²/V·s) in organic semiconductors through tailored functionalization of this scaffold.”
6. Contact for Custom Solutions
Request bulk quantities or modified derivatives:
- Email: info@vivalr.com
- Phone: (86) 15866781826
All products ship with COA, NMR, and HPLC documentation. GMP-grade batches available.
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