2-Chloro-6-methylpyridine-4-carboxylic acid

2-Chloro-6-methylpyridine-4-carboxylic Acid: Comprehensive User Guide

Table of Contents

• Product Overview & Specifications
• Key Applications & Use Cases
• Industry Case Studies
• Client Success Stories
• Contact for Custom Solutions

Product Overview & Specifications

Chemical Name: 2-Chloro-6-methylpyridine-4-carboxylic Acid
CAS No.: 73204-55-4
Molecular Formula: C8H6ClNO2
Molecular Weight: 187.59 g/mol
Appearance: White to off-white crystalline powder
Purity: ≥98% (HPLC)
Solubility: Soluble in DMSO, methanol; slightly soluble in water.

Key Applications & Use Cases

Pharmaceutical Intermediates: Critical precursor in synthesizing kinase inhibitors (e.g., EGFR inhibitors) and antiviral agents.
Agrochemicals: Building block for herbicides targeting broadleaf weeds in cereal crops.
Material Science: Ligand in metal-organic frameworks (MOFs) for gas storage applications.

Example Synthesis Process:

Step 1: Chlorination of 6-methylpyridine-4-carboxylic acid using POCl3 at 110°C.
Step 2: Recrystallization from ethanol/water mixture yields 98.2% pure product.

Industry Case Studies

Case 1: Used in continuous flow synthesis of Doramapimod (BIRB 796) intermediate, achieving 92% yield reduction in reaction time from 18h to 3h.
Case 2: Key component in development of non-selective herbicide with 40% higher foliar absorption than market alternatives.

Client Success Stories

PharmaCo Inc. (USA):
– Requirement: 15kg/month for Phase III clinical trial material
– Outcome: Consistent ≥99% purity across 8 batches, enabling FDA fast-track approval
– Testimonial: “Reliable supply chain partner for high-purity intermediates.”

AgroSolutions Ltd. (Germany):
– Application: Novel herbicide formulation
– Result: 22% cost reduction in active ingredient synthesis vs. previous pyridine derivatives
– Project Lead: Dr. Schmidt, R&D Director

Contact for Custom Solutions

Request bulk pricing, technical data sheets, or synthesis support:
Email: info@vivalr.com
Phone: (86) 15866781826