2-Methylpyrimidine: Comprehensive Technical Guide
Table of Contents
Basic Information & Specifications
| Parameter | Value |
|---|---|
| CAS Number | 5053-43-0 |
| Chemical Formula | C5H6N2 |
| Molecular Weight | 94.11 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Density | 1.02 g/cm³ |
| Boiling Point | 135-137°C |
Key Applications
2-Methylpyrimidine serves as a critical intermediate in:
- Pharmaceutical Synthesis: Production of antihypertensive drugs (e.g., Moxonidine intermediates)
- Agrochemicals: Development of pesticides and herbicides
- Specialty Chemicals: Precursor for boronic esters (e.g., Pinacol boronic ester)
- Research & Development: Building block for novel heterocyclic compounds
Synthesis Methods
| Method | Starting Materials | Yield |
|---|---|---|
| Acetamidine Hydrochloride Route | Ethyl acetimidate hydrochloride, Propionylacetic acid ethyl ester | ~81% |
| 3-Oxopentanoic Acid Amide Route | 3-Oxopentanoic acid amide | Under optimization |
Safety & Handling
- Hazards: Causes skin/eye irritation. Reacts violently with water.
- Storage: Airtight container in cool, dry, ventilated area
- PPE Requirements: Chemical-resistant gloves, goggles, and respirator
Regulatory & Customs Data
| Country | HS Code | Tariff |
|---|---|---|
| China | 29335990.90 | MFN 6.5%, VAT 17% |
| UK | 2933599590 | Standard duty applies |
Supplier & Pricing
| Product | CAS | Price (USD) | Supplier |
|---|---|---|---|
| 4-Iodo-2-Methylpyrimidine | 84586-49-2 | $250-$520 | Shanghai Yuanye Bio-Technology |
Industrial Case Studies
Case 1: Pharmaceutical Intermediate Production
A European API manufacturer utilized 2-methylpyrimidine derivatives to synthesize Moxonidine precursors, achieving 92% purity in scaled production.
Case 2: Agrochemical Development
An Asian agrochemical company developed next-generation fungicides using 2-methyl-4,6-dichloro-5-aminopyrimidine as the active moiety.
Contact Our Experts
For technical specifications, bulk pricing, or custom synthesis requirements:
| Contact Method | Details |
|---|---|
| info@vivalr.com | |
| Phone | (86) 15866781826 |
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