Table of Contents

• 1. Product Overview & Specifications
• 2. Key Applications
• 3. Step-by-Step Usage Guide
• 4. Industry Use Cases
• 5. Client Success Stories
• 6. Request Custom Solutions

1. Product Overview & Specifications

2,3,5-Collidine (CAS 6973-82-8), a trimethylpyridine derivative, is widely used in organic synthesis and pharmaceutical manufacturing.

2. Key Applications

Pharmaceutical Intermediate

Essential in synthesizing antihypertensive agents and CNS drugs through nucleophilic substitution reactions.

Catalyst Component

Improves reaction kinetics in Heck coupling reactions (TOF increase 15-20% vs. traditional catalysts).

3. Step-by-Step Usage Guide

For Suzuki-Miyaura Cross-Coupling:

1. Charge reactor with 0.1 mol% Pd(OAc)₂
2. Add 2,3,5-Collidine (1.2 equiv) under N₂
3. Maintain temperature at 80±2°C

4. Industry Use Cases

Case 1: API Manufacturing

Used in continuous flow synthesis of Rivaroxaban, achieving 92% yield (industry average: 85-88%).

5. Client Success Stories

PharmaTech Solutions (Germany)

Challenge: Side reactions in kinase inhibitor synthesis
Solution: Optimized Collidine concentration (0.8M → 1.1M)
Result: Impurities reduced from 4.2% to 0.8%

AgroChem Ltd (USA)

Challenge: Low efficiency in herbicide intermediate production
Solution: Collidine-based catalyst system
Result: Batch cycle time reduced 22%

6. Request Custom Solutions

Contact our technical team for formulation optimization or bulk pricing:

info@vivalr.com
(86) 15866781826