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Comprehensive Guide to 6-Iodoquinoline: Applications, Case Studies, and Supplier Insights

Table of Contents

1. Product Overview & Specifications

6-Iodoquinoline (CAS 13138-25-5) is a halogenated quinoline derivative widely used in pharmaceuticals, agrochemicals, and organic synthesis. Key specifications include:

Parameter Value
Molecular Formula C9H6IN
Molecular Weight 255.06 g/mol
Purity >98% (HPLC)
Appearance Pale yellow crystalline powder
Storage 2-8°C in dark, dry conditions

2. Key Applications of 6-Iodoquinoline

2.1 Pharmaceutical Intermediates

Used in synthesis of antimalarial and anticancer agents due to its bioisosteric properties.

2.2 Catalytic Cross-Coupling Reactions

Acts as a key substrate in Buchwald-Hartwig amination and Suzuki-Miyaura reactions.

3. Comparative Analysis with Similar Compounds

Compound Reactivity Cost Efficiency Typical Applications
6-Iodoquinoline High $$$ Pharma intermediates
6-Bromoquinoline Medium $$ Agrochemicals
6-Chloroquinoline Low $ Basic research

4. Step-by-Step Usage Guidelines

4.1 Handling Precautions

Use nitrile gloves and eye protection; avoid inhalation of dust.

4.2 Reaction Setup Example

For Suzuki coupling: Mix 1eq 6-iodoquinoline with 1.2eq boronic acid in degassed DME under N₂.

5. Real-World Case Studies

5.1 Case Study: Antiviral Drug Development

Client: European Pharma Company
Challenge: Synthesize novel HCV protease inhibitor
Solution: Used 6-iodoquinoline in Pd-mediated cross-coupling (92% yield)
Outcome: Accelerated preclinical development by 6 months

5.2 Case Study: OLED Material Research

Client: Asian Tech University
Challenge: Develop thermally stable electron transport layer
Solution: Incorporated 6-iodoquinoline into coordination polymer
Outcome: Achieved 15% improvement in device lifetime

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

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Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

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At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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