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Specialized in1,2,3,5-TETRA-O-ACETYL-BETA-L-RIBOFURANOSE CAS 144490-03-9and related product development and production

Chemical Name: 1,2,3,5-TETRA-O-ACETYL-BETA-L-RIBOFURANOSE
CAS No.: 144490-03-9
Molecular Fomula: C13H18O9
Molecular weight: 318.28
Appearance: Solid

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

Table of Contents

1. Product Overview

1,2,3,5-Tetra-O-acetyl-beta-L-ribofuranose (CAS 144490-03-9)

A critical acetyl-protected intermediate in nucleoside synthesis, widely used in antiviral drug development (e.g., Remdesivir analogs) and oligonucleotide research. This L-ribose derivative features four acetyl groups with β-configuration, ensuring optimal stability during glycosylation reactions.

2. Specifications & Comparative Analysis

Parameter Specification D-Ribose Analog Non-acetylated Ribose
CAS Number 144490-03-9 13035-61-5 50-69-1
Purity (HPLC) ≥98% ≥95% N/A
Storage Temp. -20°C (desiccated) 2-8°C RT
Solubility Chloroform, DCM DMSO Water

3. Key Applications

3.1 Pharmaceutical Synthesis

Essential precursor for L-nucleoside antivirals including:

  • HCV protease inhibitors
  • HIV reverse transcriptase inhibitors
  • Broad-spectrum antiviral candidates

3.2 Diagnostic Reagents

Key component in:

  • PCR probe synthesis
  • Metabolic pathway tracers
  • Enzyme activity assays

4. Usage Guidelines

4.1 Handling Protocol

  1. Thaw at RT under nitrogen atmosphere
  2. Use anhydrous solvents for dissolution
  3. Maintain reaction temp. below 40°C

4.2 Reaction Optimization

Condition Optimal Range
Molar Ratio (Nucleophile) 1:1.2-1.5
Catalyst (TMSOTf) 0.2-0.3 eq
Reaction Time 4-6 hrs

5. Industry Case Studies

5.1 Top-tier Pharma: Nucleoside Analog Production

Challenge: Achieve >90% β-selectivity in largescale synthesis
Solution: Optimized acetyl protection protocol using 144490-03-9
Outcome: 92% yield with 98.5% β-isomer purity

5.2 Biotech Startup: mRNA Vaccine Adjuvants

Challenge: Stabilize ribose core in lipid nanoparticles
Solution: Acetylated derivative incorporation
Outcome: 40% improvement in vaccine thermostability

6. Request Customized Quotation

Contact our technical specialists for:

  • Bulk pricing (kg-scale quantities)
  • Custom acetylation patterns
  • GMP-grade manufacturing options

Email: info@vivalr.com
Tel: (86) 15866781826

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Welcome to visit our factory . As the top chemical manufacturer, we have been striving for product quality, innovation , R&D, and customer service for the past 7 years. In the next 10 years or even longer, we are committed to becoming the most reliable chemical supplier in the world , creating a well-known international brand trusted by customers, with the spirit of “one meter wide, ten thousand meters deep”, we continue to focus on product research and development, continue to focus on customer service, continue to improve the supply chain service system, to create a professional chemical supply service team, to achieve win-win long-term cooperation. Please feel free to contact us if you have any questions.

Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

Does it support auditing?

Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

Whether to provide samples?

Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

User’evaluation of us

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