1,2,3,5-TETRA-O-ACETYL-BETA-L-RIBOFURANOSE CAS 144490-03-9

Table of Contents

• 1. Product Overview
• 2. Specifications & Comparative Analysis
• 3. Key Applications
• 4. Usage Guidelines
• 5. Industry Case Studies
• 6. Request Customized Quotation

1. Product Overview

1,2,3,5-Tetra-O-acetyl-beta-L-ribofuranose (CAS 144490-03-9)

A critical acetyl-protected intermediate in nucleoside synthesis, widely used in antiviral drug development (e.g., Remdesivir analogs) and oligonucleotide research. This L-ribose derivative features four acetyl groups with β-configuration, ensuring optimal stability during glycosylation reactions.

2. Specifications & Comparative Analysis

3. Key Applications

3.1 Pharmaceutical Synthesis

Essential precursor for L-nucleoside antivirals including:

• HCV protease inhibitors
• HIV reverse transcriptase inhibitors
• Broad-spectrum antiviral candidates

3.2 Diagnostic Reagents

Key component in:

• PCR probe synthesis
• Metabolic pathway tracers
• Enzyme activity assays

4. Usage Guidelines

4.1 Handling Protocol

1. Thaw at RT under nitrogen atmosphere
2. Use anhydrous solvents for dissolution
3. Maintain reaction temp. below 40°C

4.2 Reaction Optimization

5. Industry Case Studies

5.1 Top-tier Pharma: Nucleoside Analog Production

Challenge: Achieve >90% β-selectivity in largescale synthesis
Solution: Optimized acetyl protection protocol using 144490-03-9
Outcome: 92% yield with 98.5% β-isomer purity

5.2 Biotech Startup: mRNA Vaccine Adjuvants

Challenge: Stabilize ribose core in lipid nanoparticles
Solution: Acetylated derivative incorporation
Outcome: 40% improvement in vaccine thermostability

6. Request Customized Quotation

Contact our technical specialists for:

• Bulk pricing (kg-scale quantities)
• Custom acetylation patterns
• GMP-grade manufacturing options

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