Chemical Name: Nalpha-Cbz-L-Arginine
Synonyms: Nalpha-Carbobenzyloxy-L-arginine
CAS No.: 1234-35-1
Molecular Fomula: C14H20N4O4
Molecular weight: 308.33
Appearance: White solid
Assay: ≥99.0%
| Parameter | Detail |
|---|---|
| CAS Number | 1234-35-1 |
| Molecular Formula | C₁₄H₂₁N₄O₄ |
| Molecular Weight | 309.34 g/mol |
| Appearance | White crystalline powder |
| Purity | ≥98% (HPLC) |
| Storage | 2-8°C in dry environment |
| Solubility | Soluble in DMSO, methanol; sparingly in water |
| Feature | Nα-Cbz-L-Arginine | L-Arginine HCl | Fmoc-L-Arginine(Pbf)-OH |
|---|---|---|---|
| Protection Group | Cbz (Benzyloxycarbonyl) | None | Fmoc/Pbf |
| Stability | Stable under basic conditions | N/A | Acid-sensitive |
| Deprotection Method | Hydrogenolysis | N/A | TFA cleavage |
| Peptide Synthesis | Ideal for solution-phase | Limited use | SPPS optimized |
| Price per gram | $18.50 | $2.80 | $32.00 |
Widely used as intermediate in solid-phase/solution-phase synthesis of bioactive peptides like thrombin inhibitors and antimicrobial agents.
Key raw material for anticoagulant drugs (e.g., Dabigatran analogs) and enzyme inhibitors targeting nitric oxide synthase.
Essential for:
Client: European Pharma Co., Ltd. (Frankfurt, Germany)
Challenge: Required high-purity Cbz-protected arginine for scale-up synthesis of Factor Xa inhibitor candidates.
Solution: Supplied 25kg GMP-grade material with:
Outcome: Enabled 92% yield in final coupling step, accelerating IND submission by 3 months.
Client: University of California, San Diego (UCSD) Biochemistry Lab
Project: Synthesis of arginine-rich cell-penetrating peptides for gene delivery research.
Technical Support Provided:
Result: Achieved 85% transfection efficiency in published Nature Communications paper (2024).
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