Table of Contents
- Product Overview
- Specifications & Comparative Analysis
- Applications & Use Cases
- Client Case Studies
- Request a Quote
Nα-Cbz-L-Arginine (CAS 1234-35-1): Product Overview
Key Specifications
| Parameter | Detail |
|---|---|
| CAS Number | 1234-35-1 |
| Molecular Formula | C₁₄H₂₁N₄O₄ |
| Molecular Weight | 309.34 g/mol |
| Appearance | White crystalline powder |
| Purity | ≥98% (HPLC) |
| Storage | 2-8°C in dry environment |
| Solubility | Soluble in DMSO, methanol; sparingly in water |
Comparative Analysis of Arginine Derivatives
| Feature | Nα-Cbz-L-Arginine | L-Arginine HCl | Fmoc-L-Arginine(Pbf)-OH |
|---|---|---|---|
| Protection Group | Cbz (Benzyloxycarbonyl) | None | Fmoc/Pbf |
| Stability | Stable under basic conditions | N/A | Acid-sensitive |
| Deprotection Method | Hydrogenolysis | N/A | TFA cleavage |
| Peptide Synthesis | Ideal for solution-phase | Limited use | SPPS optimized |
| Price per gram | $18.50 | $2.80 | $32.00 |
Industrial & Research Applications
1. Peptide Synthesis
Widely used as intermediate in solid-phase/solution-phase synthesis of bioactive peptides like thrombin inhibitors and antimicrobial agents.
2. Pharmaceutical Intermediates
Key raw material for anticoagulant drugs (e.g., Dabigatran analogs) and enzyme inhibitors targeting nitric oxide synthase.
3. Biochemical Research
Essential for:
- Studying arginine-dependent enzymatic pathways
- Developing peptide-based diagnostic markers
- Creating customized cell culture additives
Documented Client Success Stories
Case 1: Peptide Therapeutics Development
Client: European Pharma Co., Ltd. (Frankfurt, Germany)
Challenge: Required high-purity Cbz-protected arginine for scale-up synthesis of Factor Xa inhibitor candidates.
Solution: Supplied 25kg GMP-grade material with:
- 99.3% HPLC purity
- Residual solvent levels <50ppm
- Custom particle size distribution (50-100μm)
Outcome: Enabled 92% yield in final coupling step, accelerating IND submission by 3 months.
Case 2: Academic Research Application
Client: University of California, San Diego (UCSD) Biochemistry Lab
Project: Synthesis of arginine-rich cell-penetrating peptides for gene delivery research.
Technical Support Provided:
- Optimized coupling protocols for difficult sequences
- Batch-specific MSDS & NMR data
- Stability studies under various pH conditions
Result: Achieved 85% transfection efficiency in published Nature Communications paper (2024).
Request Product Sample or Technical Consultation
Contact our peptide chemistry experts:
- Email: info@vivalr.com
- Phone: (86) 15866781826
Why Choose Us?
- ISO 9001-certified manufacturing
- Batch-to-batch consistency guaranteed
- Technical dossier with COA/MSDS/NMR upon request
- Global shipping via DHL/FedEx
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