3-Bromo-5-fluoropyridine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
3-Bromo-5-fluoropyridine (CAS 407-20-5) is a halogenated pyridine derivative with broad utility in organic synthesis. Its molecular formula is C5H3BrFN, and it has a molecular weight of 175.99 g/mol.
Key Specifications:
| Parameter | Value |
|---|---|
| Appearance | Colorless to pale yellow liquid |
| Density | 1.7±0.1 g/cm³ |
| Boiling Point | 152.5±20.0 °C |
| Melting Point | 24-28°C |
| Flash Point | 46.0±21.8 °C |
Safety Data:
- Hazard Codes: H302 (Harmful if swallowed), H315 (Causes skin irritation), H318 (Causes serious eye damage), H335 (May cause respiratory irritation)
- Precautionary Measures: Use PPE, avoid inhalation, and store in a cool, ventilated area.
2. Applications & Use Cases
3-Bromo-5-fluoropyridine serves as a critical intermediate in:
- Pharmaceuticals: Synthesis of antiviral and anticancer agents.
- Agrochemicals: Building block for herbicides and fungicides.
- Material Science: Precursor for functionalized polymers and ligands.
Example Workflow:
In drug development, it is used to introduce fluorine and bromine substituents into pyridine rings, enhancing bioactivity and metabolic stability.
3. Industry Case Studies
Case Study 1: Shanghai Yuanye Bio-Technology Co., Ltd.
- Application: Synthesis of fluorinated pyridine carboxylates for kinase inhibitors.
- Outcome: Achieved 98% purity in final API intermediates, reducing downstream purification costs.
Case Study 2: HeWu Biochemical Co., Ltd.
- Application: Development of novel agrochemical intermediates.
- Outcome: Improved reaction yield by 22% compared to traditional bromination methods.
4. Contact for Inquiries
For pricing, technical data, or custom synthesis requests, contact our team:
- Email: info@vivalr.com
- Tel: (86) 15866781826


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