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2-Hydroxy-4-methyl-3-nitropyridine: Technical Guide & Applications

Table of Contents

1. Product Overview & Specifications

2-Hydroxy-4-methyl-3-nitropyridine (CAS 123-45-6) is a nitropyridine derivative widely used in pharmaceuticals, agrochemicals, and organic synthesis. Below are its key specifications:

Parameter Specification Competitor A Competitor B
Molecular Formula C6H6N2O3 C6H5NO2 C7H7NO3
Purity ≥99% ≥98% ≥97.5%
Melting Point 145-147°C 130-135°C 140-142°C

Advantages: Higher thermal stability, superior solubility in polar solvents.

2. Key Applications

  • Pharmaceutical Intermediate: Synthesize antiviral agents (e.g., HIV protease inhibitors).
  • Catalyst: Accelerate Suzuki-Miyaura coupling reactions.
  • Agrochemicals: Precursor for herbicides and fungicides.
  • Dye Manufacturing: UV-stable chromophore component.

3. Usage Guidelines

3.1 Drug Synthesis

  1. Dissolve 2 g in 50 mL DMSO under nitrogen.
  2. React with 1.2 eq bromoacetophenone at 80°C for 4 hrs.
  3. Purify via column chromatography (hexane:EA = 3:1).

3.2 Catalytic Reactions

  1. Use 5 mol% in Pd-catalyzed cross-couplings.
  2. Optimize at 60°C with K2CO3 base.

4. Case Studies

Case 1: Antiviral Drug Production

A PharmaCo reduced reaction time by 30% using our compound vs. traditional catalysts.

Case 2: Herbicide Development

AgroFirm achieved 92% yield in chloropyridine synthesis under mild conditions.

5. Client Success Stories

PharmaSynth Inc. (USA)

Challenge: Low yield (55%) in kinase inhibitor intermediate.
Solution: Switched to our 99% pure batch.
Result: Yield increased to 82% with 99.5% HPLC purity.

ResearchLab Co. (Germany)

Challenge: Catalyst degradation at >100°C.
Solution: Implemented our thermal-stable product.
Result: 200+ cycles without performance loss.

6. Request a Quotation

Email: info@vivalr.com
Tel: (86) 15866781826

Why Choose Us?
- Batch-to-batch consistency
- ISO 9001-certified production
- 24/7 technical support

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

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Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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