3,5-Dichloro-4-hydroxypyridine

Comprehensive Guide to 3,5-Dichloro-4-hydroxypyridine

Product Overview

3,5-Dichloro-4-hydroxypyridine (CAS 17228-64-7) is a halogenated pyridine derivative with molecular formula C₅H₃Cl₂NO and molecular weight 163.99 g/mol. This heterocyclic compound features two chlorine substituents at positions 3 and 5, along with a hydroxyl group at position 4, enabling versatile reactivity in organic synthesis.

Technical Specifications & Comparative Analysis

Industrial Applications

Pharmaceutical Intermediates

Critical building block for antiviral agents and kinase inhibitors due to its hydrogen bonding capacity and metabolic stability.

Agrochemical Synthesis

Used in fungicide formulations targeting botrytis cinerea and powdery mildew through foliar application systems.

Coordination Chemistry

Acts as bidentate ligand for transition metal catalysts in cross-coupling reactions (Suzuki, Buchwald-Hartwig).

Documented Use Cases

Case 1: Antibiotic Intermediate Production

Client: European Pharma Manufacturer
Application: Synthesis of quinolone-class antibiotics
Result: 22% yield improvement vs. previous synthesis route

Case 2: Crop Protection Formulation

Client: Asian Agrochemical Company
Application: Systemic fungicide for rice blast control
Result: 98% disease suppression at 200 ppm concentration

Operational Guidelines

• Store under inert atmosphere at 2-8°C
• Handle with nitrile gloves and chemical goggles
• Solubility: 8.3g/L in DMSO at 25°C
• Incompatible with strong oxidizers and alkali metals

Technical & Commercial Inquiry

For batch-specific COA, bulk pricing (100kg+), or custom synthesis requirements:

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